What It Is Used For

  • Contrave is a prescription medication for weight management in adults with obesity or overweight who have at least one weight-related condition, such as type 2 diabetes, high blood pressure, or high cholesterol.
  • It should be used as part of a comprehensive program that includes a reduced-calorie diet and regular physical activity.

How It Works

  • Contrave is a combination of two medications:
    • Naltrexone: Typically used for alcohol and opioid dependence, it may help reduce food cravings.
    • Bupropion: Often prescribed for depression and smoking cessation, it may help reduce appetite.
  • Together, they act on areas of the brain that control hunger and reward, helping to reduce cravings and overeating.

How It’s Taken

  • Contrave is an oral medication taken in tablet form.
  • Dosing is gradually increased over four weeks to minimize side effects. The usual target dose is two tablets twice daily (morning and evening).
  • Tablets should be swallowed whole and not crushed, chewed, or divided.
  • Avoid taking Contrave with high-fat meals, as this can increase the risk of side effects.

Potential Side Effects

  • Common side effects: Nausea, constipation, headache, dizziness, dry mouth, and trouble sleeping (insomnia).
  • Serious side effects: Increased risk of seizures (especially in people with a history of seizures), elevated blood pressure, and liver problems.
  • Mental health concerns: Bupropion may increase the risk of suicidal thoughts or behaviors, particularly in younger patients. Notify your doctor if you notice mood changes, depression, or anxiety.

Precautions and Lifestyle Tips

  • Medical history: Inform your doctor if you have a history of seizures, eating disorders, uncontrolled high blood pressure, or opioid use, as Contrave may not be suitable for you.
  • Avoid opioids: Do not take Contrave if you are using opioid medications, as naltrexone can block their effects and cause withdrawal symptoms.
  • Alcohol and drug interactions: Limit alcohol use and discuss all medications or supplements you are taking with your doctor to prevent interactions.
  • Monitoring: Regular follow-ups are necessary to monitor weight loss progress, blood pressure, and any side effects.
  • Lifestyle changes: Combining Contrave with diet, exercise, and behavioral modifications improves the likelihood of success.